Topics Map > Features and Functionality > Client Capabilities > Desktop
Office 365 (Outlook 2016 for MacOS) - Change Reply To Address
Outlook 2016 for Mac do not support the ability to change the reply to address.
There is a work around for Outlook 2016 for Mac by using the "Send As" and "Send on Behalf of" permissions.
Note: This work around assumes that you have been granted the appropriate permissions.