WRAP Data Freeze - "APG" RiskScore Explanation

This is the explanation of the "APG" RiskScore field.

Descriptions of APOE_RiskScore variable:

A risk score based on the apolipoprotein E (APOE) gene was calculated, with a
higher risk score indicating having a higher amount of genetic risk for Alzheimer’s
disease (Darst, et al. in review). APOE was coded by the e2/e3/e4 genotype formed
by rs7412 and rs429358. Risk due to APOE status was calculated according to the odds
ratio (OR) of the e2/e3/e4 genotype, as indicated in the meta-analysis of APOE
genotype frequencies in studies reported in AlzGene[1]. These ORs were based on studies of
Caucasian individuals and were calculated using the e2/e2 genotype as the reference
(e2/e2 OR=1) as follows: e2/e3 OR=1.38, e3/e3 OR=2.00, e2/e4 OR=4.45, e3/e4 OR=6.78,
e4/e4 OR=25.84.

Note that the 'APOE_RiskScore' reported here is the natural logarithm (ln) of
the OR.

Document History
Version DateEffective DateChange ReasonPrimary Author
August 6, 2020
Original Allen Wenzel
April 1, 2020
Committee updates/page reorgIan Canovi

Keywords:riskscore   Doc ID:104729
Owner:Allen W.Group:Wisconsin Alzheimer’s Program
Created:2020-08-06 15:43 CSTUpdated:2020-09-18 14:24 CST
Sites:Wisconsin Alzheimer’s Program
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