Freeze:

This documentation pertains to the Freeze 2025_May of the longitudinal PET data (11CPIB) for the ADRC & WRAP cohorts, as collected by the Wisconsin Alzheimer's Disease Research Center.

Counts:

This imaging dataset includes 1473 PiB scans on 762 participants (219 ADRC; 543 WRAP).

There are 1427 PiB SUVR results on 739 participants (207 ADRC; 532 WRAP; 351 with one scan, 227 with two scans, 59 with three scans, and 102 with four+ scans; 498 female; 71 URG; 61 MCI and 17 Dementia at first visit; 75 MCI and 21 Dementia at last visit; < 5 participant(s) are aged 90+, of those not: mean first and last ages of 65.5 and 68.3, respectively; mean first and last days since baseline of 3260 and 4323, respectively).

There are 1441 PiB DVR results on 749 participants (218 ADRC; 531 WRAP; 362 with one scan; 226 with two scans, 58 with three scans, and 103 with four+ scans; 504 female; 68 URG; 64 MCI and 17 Dementia at first visit; 77 MCI and 22 Dementia at last visit; < 5 participant(s) are aged 90+, of those not: mean first and last ages of 65.5 and 68.4, respectively; mean first and last days since baseline of 3272 and 4324, respectively).

There are 4173 PiB visual rating results on 762 participants (219 ADRC; 543 WRAP; 363 with one scan, 236 with two scans, 58 with three scans, and 105 with four+ scans; 512 female; 72 URG; 68 MCI and 18 Dementia at first visit; 81 MCI and 23 Dementia at last visit; < 5 participant(s) are aged 90+, of those not: mean first and last ages of 66.0 and 68.9, respectively; mean first and last days since baseline of 3263 and 4320, respectively).

Per data sharing agreements with the Oneida nation, data from Native American participants are not included in this dataset.

STRUCTURE:

Subdirectories are arranged as follows:

sub-<subject label>/
    ses-<session label>/
        anat/
            sub-<subject label>_ses-<session label>_T1w.nii.gz          # T1-weighted MRI
        pet/
            sub-<subject label>_ses-<session label>_trc-11CPIB.nii.gz         # PET data
            sub-<subject label>_ses-<session label>_trc-11CPIB.json         # JSON describing DTI
derivatives/
    pib_dvr/
        pib_dvr_aal.tsv         # combined PiB DVR ROI-level values - aal atlas
        pib_dvr_homic.tsv         # combined PiB DVR ROI-level values - homic atlas
        pib_dvr_long.tsv         # combined PiB DVR ROI-level values - all atlases in long format
        pib_dvr_morimod.tsv         # combined PiB DVR ROI-level values - morimod atlas

    pib_suvr/
        pib_suvr_aal.tsv         # combined PiB SUVR ROI-level values - aal atlas
        pib_suvr_homic.tsv         # combined PiB SUVR ROI-level values - homic atlas
        pib_suvr_long.tsv         # combined PiB SUVR ROI-level values - all atlases in long format
        pib_suvr_morimod.tsv          # combined PiB SUVR ROI-level values - morimod atlas

    visual_rating/
        pib_visual_ratings.tsv         # combined PiB visual rating

<subject label> represents the subject's study identifier.
<session label> represents the subject's integer age at the time of the PET scan.

DERIVED VARIABLES:

Within pib_dvr_aal.tsv

• pib_index: cortical DVR average (ROIs: angular gyrus, anterior cingulate gyrus, posterior cingulate gyrus, frontal medial orbital gyrus, precuneus, supramarginal gyrus, middle temporal gyrus, superior temporal gyrus

Within pib_suvr_aal.tsv

• centiloid: ratio of mean signal in cerebellum VOI (reference region) and cortical VOI (signal volume), transformed to 0-100 scale (0 is the average of a younger cohort with healthy brains. 100 is the average of an AD cohort).

Within pib_visual_ratings.tsv

• rating: PiB visual rating (a rating of 3 is clearly Positive; 0, 1, or 2 is Negative)

REFERENCES:

Papers describing the construction of the cortical DVR average (pib_index):

Sprecher KE, Bendlin BB, Racine AM, et al. Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults. Neurobiol Aging. 2015;36(9):2568-2576. https://doi.org/doi:10.1016/j.neurobiolaging.2015.05.004.

Racine AM, Koscik RL, Nicholas CR, et al. Cerebrospinal fluid ratios with Aß42 predict preclinical brain ß-amyloid accumulation. Alzheimers Dement (Amst). 2016;2:27-38. https://doi.org/doi:10.1016/j.dadm.2015.11.006.

Papers describing the construction of PiB SUVR centiloids (centiloid):

Klunk WE, Koeppe RA, Price JC, et al. The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement. 2015;11(1):1-15.e154. https://doi.org/doi:10.1016/j.jalz.2014.07.003.

Betthauser TJ, Bilgel M, Koscik RL, et al. Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts [published correction appears in Brain. 2023 Feb 13;146(2):e11. doi: 10.1093/brain/awac390.]. Brain. 2022;145(11):4065-4079. https://doi.org/doi:10.1093/brain/awac213. 

Papers describing the construction of the visual rating (rating):

Johnson SC, Christian BT, Okonkwo OC, et al. Amyloid burden and neural function in people at risk for Alzheimer's Disease. Neurobiol Aging. 2014;35(3):576-584. https://doi.org/doi:10.1016/j.neurobiolaging.2013.09.028. 

Funding/Acknowledgments:

Papers including data obtained from these images should acknowledge NIH R01 AG027161 (the Wisconsin Registry for Alzheimer's Prevention) and/or NIH P30 AG062715 (the Wisconsin Alzheimer's Disease Research Center).

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