Freeze:

This documentation pertains to the Freeze 2024_November of the longitudinal PET data (18FNAV4694) for the ADRC & WRAP cohorts, as collected by the Wisconsin Alzheimer's Disease Research Center.

Counts:

This imaging dataset includes 42 NAV4694 scans on 42 participants (8 ADRC; 34 WRAP).

There are 41 NAV4694 SUVR results on 41 participants (8 ADRC; 33 WRAP; 41 with one scan, 0 with two+ scans; 35 female; 10 URG; 1 MCI and 1 Dementia at first visit; 1 MCI and 1 Dementia at last visit; 0 participant(s) are aged 90+, of those not: mean first and last ages of 65.4 and 65.4, respectively; mean first and last days since baseline of 4791 and 4791, respectively).

All of the above applies to NAV4694 visual rating results.

Per data sharing agreements with the Oneida nation, data from Native American participants are not included in this dataset.

STRUCTURE:
Subdirectories are arranged as follows:

sub-<subject label>/
    ses-<session label>/
        anat/
            sub-<subject label>_ses-<session label>_T1w.nii.gz          #T1-weighted MRI
        pet/
            sub-<subject label>_ses-<session label>_trc-18FNAV4694.nii.gz         # PET data
            sub-<subject label>_ses-<session label>_trc-18FNAV4694.json         # JSON describing DTI
derivatives/
    nav4694_suvr
        nav4694_suvr_aal.tsv         # combined NAV4694 SUVR ROI-level values - aal atlas
        nav4694_suvr_homic.tsv         # combined NAV4694 SUVR ROI-level values - homic atlas
        nav4694_suvr_long.tsv         # combined NAV4694 SUVR ROI-level values - all atlases in long format
        nav4694_suvr_morimod.tsv         # combined NAV4694 SUVR ROI-level values - morimod atlas

    visual_rating/
        nav4694_visual_ratings.tsv         # combined NAV4694 visual rating

<subject label> represents the subject's study identifier.
<session label> represents the subject's integer age at the time of the PET scan.

DERIVED VARIABLES:

Within nav4694_visual_rating.tsv

• rating: NAV4694 visual rating (a rating of 3 is clearly Positive; 0, 1 or 2 is clearly Negative)

Funding/Acknowledgments:

Papers including data obtained from these images should acknowledge NIH R01 AG027161 (the Wisconsin Registry for Alzheimer's Prevention) and/or NIH P30 AG062715 (the Wisconsin Alzheimer's Disease Research Center).

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