Microsoft 365 (Outlook for Windows) - Outlook can't set up a new profile using Exchange Autodiscover
Recommended method
Run Office 365 Support and Recovery Assistant
Install and run Microsoft Office 365 Support and Recovery Assistant. You can download this tool by following this link: Microsoft Support and Recovery Assistant.
This tool will automatically diagnose any issues with your Office 365 account and provide you with relevant fixes.
Additional methods
Upgrade to the latest version of Outlook/Office
Install/upgrade to Office 365: Microsoft 365 - Microsoft 365 Installation Information. Important: you may need to uninstall previous version of Office before installing Office 365 version.
Windows Update
Update your Windows operating system (make sure to include other Microsoft software within the update process): Windows - Using Windows Update.
Reset/Remove your account credentials from within your OS
Remove Microsoft account credentials: https://kb.wisc.edu/page.php?id=60885.
Recreate your local OST file
- Open Outlook and click File near the top-left corner.
- On this page, click Account Settings then click Account Settings from the context menu.
- This will open a new window, click the Data Files tab near the top.
- On this tab, select an account and click Open File Location... which will open the file location in File Explorer.
- Close Outlook, but keep the File Explorer window open.
- Delete the OST (.ost) file and close File Explorer.
- Restart Outlook.
Create a new profile
First, remove your current profile: Microsoft 365 (Outlook for Windows) - Remove an Outlook Profile. Then, add a new profile: Microsoft 365 (Outlook for Windows) - Configure Outlook.
Waiting a period of time or retrying
In some cases, waiting a period of time (30-60 minutes), restarting computer, and retry configuration may work.