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Single IRB Review Partners

The Health Sciences IRBs participate in a variety of IRB reliance partnerships, all designed to streamline the IRB review process for multisite and collaborative research studies. The status, scope, and process for each reliance partnership differ. Please see below for additional information on each partnership and please email our Reliance Team ( with any questions.


The Health Sciences IRBs office has helped lead the NIH-funded SMART IRB initiative to enable single IRB review for multisite studies. SMART IRB is a flexible, national IRB reliance agreement that has been signed by over 350 institutions across the country, including most major academic medical centers. The SMART IRB website also has a number of resources helpful for researchers conducting multisite studies. Please contact the Reliance Team to find out whether SMART IRB might be useful for your study.

Greater Plains Collaborative (GPC)

The GPC is a network of ten medical centers focused on improving healthcare delivery through ongoing learning, adoption of evidence-based practices, and active research dissemination. The GPC has an IRB reliance agreement that has been finalized. Please see the Greater Plains Cooperative (GPC) Reliance Fact Sheet for more information about participating institutions and the GPC reliance process.

UnityPoint Health - Meriter & UW Partnership

Established in 2008, the UnityPoint Health - Meriter & UW Partnership is an agreement that allows certain studies involving both institutions to be reviewed by a single IRB of record. Details about what studies qualify for review by a single IRB as well as instructions for using this partnership are provided below.

National Cancer Institute Central IRB (NCI CIRB)

The HS IRBs have an IRB reliance agreement with the NCI CIRB, which provides centralized IRB oversight for institutions conducting certain types of oncology trials. Eligible studies must obtain institutional sign-off through the completion of the request to cede review to an external IRB application in ARROW. Please see UW-Madison Procedures for Using the National Cancer Institute Central Institutional Review Board (NCI CIRB) for more information.

Keywords:partnerships, BTCRC, GPC, MARCH, Meriter, NCI CIRB, MWPSC, NIRI, NCATS, StrokeNet, multisite, IRB of record, defer, Single IRB, Central IRB, External IRB   Doc ID:48589
Owner:Monica E.Group:Health Sciences IRBs
Created:2015-03-10 10:03 CSTUpdated:2018-08-15 08:08 CST
Sites:Health Sciences IRBs
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