Single IRB Review FAQS
What is single IRB review? Single IRB review means that a single IRB of record (aka Reviewing IRB) conducts the ethical review for sites participating in a multi-site study. To use a single IRB, institutions must enter into formal arrangements called reliance agreements to document which institution will serve as the Reviewing IRB and which will cede IRB review to that institution. How could single IRB review affect my federal funding proposal? Single IRB review requirements can affect:
- The types of documents and assurances that need to be included in your funding application – you may need letters of support from a UW IRB and other participating institutions in support of single IRB review.
- Study budgets – additional personnel and services may be required in support of the multi-site research and costs for the Reviewing IRB may need to be included.
- Sign offs needed before a funding proposal can be forwarded – a UW IRB must agree to the proposed Reviewing IRB cited in any funding application and provide documentation of that support.
- information to include in your grant
- the appropriate IRB to oversee the research
- budgeting for IRB review
- putting together a communication plan, which is required by the NIH policy
- other implications of the single IRB review policy for the study team, such as additional roles and responsibilities the study team may incur as a result of using a single IRB.