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Office 365 (Thunderbird) - Set a vacation message (out of office)
This document contains instructions on using a non-Microsoft email client, such as Apple Mail or Thunderbird. Microsoft does not recommend these clients for use with Office 365, and there are often significant limitations in client functionality as a result. Because of this, the DoIT Help Desk is only able to offer best effort support for these clients, and certain issues may require the use of a Microsoft client in order to be resolved. For more information on Office 365 client support, please see: Office 365 - Which clients/protocols will be supported?.Best Effort Support Only
Thunderbird has no native support for Vacation/Out of Office Messages
However, you can configure your email account through the Outlook Web App to send a Vacation Message to all incoming messages.
For more on why Thunderbird has no native support, please click here.