EASY Does It: Andrographis Herb for COVID

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The EASY guide to deciding whether to try something for COVID

When you are choosing whether or not to do something for your health, take it EASY! All four factors - 1) Effects, 2) Access, 3) Safety, and 4) You – can help you make a decision.

Tom heard about an herb called Andrographis that might help to make symptoms of COVID less severe or even shorten the length of feeling sick if he got COVID. He wanted to know more so he used the EASY guide to help him decide if this herb was worth a try:

Effects: Andrographis paniculata (AP) is an herb used traditionally in Indian and Chinese medicine for several conditions, including the common cold. COVID is a disease that can cause symptoms like the common cold including sinus congestion, sore throat, fever, and cough. There is no research yet on treating COVID with AP. Some studies in cells found that AP may have anti-inflammatory effects and help the immune system, the body’s way of fighting off infections.¹ Several studies in people with cold symptoms have found that if people started taking AP within the first 24-48 hours of feeling sick, it might keep symptoms like sore throat, fever, nasal congestion, and cough from getting bad and shorten the total time of feeling sick compared to taking a placebo.^2-6 In one small study AP worked better than Echinacea if started early in uncomplicated common colds.⁶ Many of these studies were done with specific products and ones in which AP was combined with the other herbs. So, more research is needed to know if the helpful effects were due to AP, the specific products, or the combination of herbs. Taking AP may be helpful to prevent the common cold, but more research is needed to know for sure.⁷

Access: The leaves and above-ground parts of AP are the most commonly used and studied and most products are made from extracts of these plant parts. Check the label to make sure. AP is commonly available in recent years and comes in capsule, tablet, and alcoholic tincture. Many products are standardized to 10-35% andrographolides, often considered a main active compound in AP. This is done to make sure the product is concentrated enough to be effective. Cost varies, but online, the average cost of 60 capsules would be about $7.30. Look for a reputable manufacturer and supplier to be assured of a quality product.

Safety: The amount of AP used for the common cold in research studies ranged from 450 mg to almost 2,000 mg of AP extract daily (divided into 3 to 4 doses) for 5 to 7 days. Side effects were rare and mild.^2-6 Doses of up to 6 grams daily for 7 days have been used with apparent safety.⁶ In the one prevention study, 200 mg per day (in divided doses) was used for 3 months, but more long-term studies are needed to know what the best dose of AP is for prevention.

You: Tom is 45 years old and is generally healthy, with no major health problems. If he had an existing health condition like heart disease or diabetes, AP might be helpful, but he would want to be sure to work closely with his doctor if he came down with symptoms of COVID-19.

Tom decides that AP sounds safe enough to try and that he will buy some to have on hand if he starts feeling sick

NOTE: Dietary supplements are intended to supplement the diet. They are not medicines and are not intended to treat, diagnose, mitigate, prevent, or cure disease. In some cases, dietary supplements may have unwanted effects, especially if taken before surgery or with other dietary supplements or medicines, or if you have certain health conditions. Also, supplements are not regulated with the same degree of oversight as medications. Products vary greatly in terms of accuracy of labels, presence of contaminants, and the validity of claims on the label. Work with your health care provider to determine how best to achieve optimal health.

What we know about integrative health care has come to us thanks to the efforts, experiences, and collective wisdom of people from many cultures and backgrounds. We wish to acknowledge all the healers, researchers, patients, and peoples who have informed the content of this tool.

Author(s)

This handout was adapted for the Osher Center for Integrative Health at the University of Wisconsin-Madison from the original by Sara Arscott, PhD, and Adam Rindfleisch, MD.

Date Created: May 2020

References

1. Chandrasekaran CV, Murali B, Deepak M, Agarwal A. In vitro comparative evaluation of non-leaves and leaves extracts of Andrographis paniculata on modulation of inflammatory mediators. Antiinflamm Antiallergy Agents Med Chem. 2012;11(2):191-7. doi:10.2174/187152312803305731
2. Therapeutic Research Center (TRC). Natural Medicines. Health & Wellness online database: Andrographis. Accessed March 7, 2025. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=973
3. Hu XY, Wu RH, Logue M, et al. Andrographis paniculata (Chuān Xīn Lián) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis. PLoS One. 2017;12(8):e0181780.
4. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med. Apr 2004;70(4):293-8. doi:10.1055/s-2004-818938
5. Poolsup N, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. Journal of clinical pharmacy and therapeutics. Feb 2004;29(1):37-45. doi:10.1046/j.1365-2710.2003.00534.x
6. Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G. Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res. Jan 2004;18(1):47-53. doi:10.1002/ptr.1359
7. Cáceres DD, Hancke JL, Burgos RA, Wikman GK. Prevention of common colds with Andrographis paniculata dried extract. A Pilot double blind trial. Phytomedicine. Jun 1997;4(2):101-4. doi:10.1016/s0944-7113(97)80051-7